Hedgehogs in the clinic.

作者: Andrew P. McMahon , Pao-Tien Chuang

DOI: 10.1038/NM1296-1308

关键词:

摘要: Components of the hedgehog signaling pathways play key roles during embryonic development and in several human diseases.

参考文章(25)
Mark J. Bitgood, Andrew P. McMahon, HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo Developmental Biology. ,vol. 172, pp. 126- 138 ,(1995) , 10.1006/DBIO.1995.0010
Erich Roessler, Elena Belloni, Karin Gaudenz, Philippe Jay, Philippe Berta, Stephen W Scherer, Lap-Chee Tsui, Maximilian Muenke, None, Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nature Genetics. ,vol. 14, pp. 357- 360 ,(1996) , 10.1038/NG1196-357
J. A. Porter, K. E. Young, P. A. Beachy, Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development Science. ,vol. 274, pp. 255- 259 ,(1996) , 10.1126/SCIENCE.274.5285.255
Johan Ericson, Susan Morton, Atsushi Kawakami, Henk Roelink, Thomas M Jessell, Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity Cell. ,vol. 87, pp. 661- 673 ,(1996) , 10.1016/S0092-8674(00)81386-0
E Belloni, M Muenke, E Roessler, G Traverse, J Siegel-Bartelt, A Frumkin, HF Mitchell, H Donis-Keller, C Helms, AV Hing, HHQ Heng, B Koop, D Martindale, JM Rommens, L-C Tsui, SW Scherer, None, Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly Nature Genetics. ,vol. 14, pp. 353- 356 ,(1996) , 10.1038/NG1196-353
Yann Echelard, Douglas J. Epstein, Benoit St-Jacques, Liya Shen, Jym Mohler, Jill A. McMahon, Andrew P. McMahon, Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity Cell. ,vol. 75, pp. 1417- 1430 ,(1993) , 10.1016/0092-8674(93)90627-3
Donna M. Stone, Mary Hynes, Mark Armanini, Todd A. Swanson, Qimin Gu, Ronald L. Johnson, Matthew P. Scott, Diane Pennica, Audrey Goddard, Heidi Phillips, Markus Noll, Joan E. Hooper, Frederic de Sauvage, Arnon Rosenthal, The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog Nature. ,vol. 384, pp. 129- 134 ,(1996) , 10.1038/384129A0
A. Vortkamp, K. Lee, B. Lanske, G. V. Segre, H. M. Kronenberg, C. J. Tabin, Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein Science. ,vol. 273, pp. 613- 622 ,(1996) , 10.1126/SCIENCE.273.5275.613
Christiane Nüsslein-Volhard, Eric Wieschaus, Mutations affecting segment number and polarity in Drosophila Nature. ,vol. 287, pp. 795- 801 ,(1980) , 10.1038/287795A0