Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model.

摘要: Advances in nanomedicine are expected to escalate the coming years, particularly related availability and delivery of optimum dosage. It is crucial that dissolution behavior such novel dosage forms be adequately scrutinized maximize their therapeutic benefits. In this work, irregularly shaped nanoparticles was analyzed using a modified negative-two-thirds-root diffusion model (with shape factor, sigma, incorporated into equation describe evolution). The shown effective describing transition from peanut-shape (connected by bridges) discrete spheres during process. Due eventual aggregation solution, description limited aggregate as whole. Scanning electron microscopy, layer thickness calculations, sonication studies provide information show that, dissolution, bridges dissolve, yielding which then randomly solution. Viscosity experiments reveal predominantly diffusion-controlled. solution described going bridged particles particles, aggregates, finally full dissolution.