To poly(I:C) or not to poly(I:C): advancing preclinical schizophrenia research through the use of prenatal immune activation models.

摘要: The neurodevelopmental hypothesis of schizophrenia has been highly influential in shaping our current thinking about modeling the disease animals. Based on findings provided by human epidemiological studies, a great deal recent interest centered upon establishment rodent models which basic experimental manipulation takes form prenatal exposure to infection and/or immune activation. One such model is based treatment with inflammatory agent poly(I:C) (=polyriboinosinic-polyribocytidilic acid), synthetic analog double-stranded RNA. Since its initial and application research, made impact researchers concentrating neuroimmunological basis complex brain disorders as schizophrenia, consequence, now enjoys wide recognition international scientific community. present article emphasizes that gained because it successfully accounts for several aspects epidemiology, pathophysiology, symptomatology, treatment. numerous features this system make very powerful animal schizophrenia-relevant expected be capable critically advancing knowledge how brain, following an (immune-associated) triggering event early life, can develop into "schizophrenia-like brain" over time. Furthermore, seems suitable exploration novel pharmacological neuro-immunomodulatory strategies both symptomatic preventive treatments against psychotic disease, well identification neurobiological mechanisms underlying gene-environment environment-environment interactions presumably involved etiology related disorders.