Development of Functional Response in Human Exocrine Pancreas

摘要: The ability of newborns to digest proteins, fats, and carbohydrates depends, a large extent, on their level exocrine pancreatic function. Building the limited published data, we studied enzyme activities in duodenal fluid response pancreas secretogogues 15 premature full-term infants at birth 30 days age. We compared these findings those obtained from identical studies 17 children age 2 years above. In addition, measured exopeptidase, carboxypeptidase B, relation other enzymes. contained no amylase negligible lipase. Carboxypeptidase B levels were also low older children. contrast, chymotrypsin activity was about 50% 60% found Trypsin activity, highest all enzymes measured, same both children, with transient increase days. Administration pancreozymin had effect slight 1-month-old infants. But by years, full evident. newborns, responses secretin poor. Thus, secretory human secretogogues, absent or minimal birth, is acquired during postnatal period.