Safety, Tolerance, and Pharmacokinetics of Cefepime Administered Intramuscularly to Healthy Subjects

摘要: Steady state pharmacokinetics, absolute bioavailability, and dose proportionality of cefepime were evaluated in healthy male subjects after single (250, 500, 1000, or 2000 mg) multiple (1000 mg every 12 hours for 10 days) intramuscular injections. Safety tolerance also monitored. High performance liquid chromatography/UV methodology was used to determine concentrations plasma urine. Key pharmacokinetic parameters determined using noncompartmental methods. Cefepime absorbed rapidly; mean peak times 1.0-1.6 hours. Pharmacokinetics linear over the 250-mg 2000-mg range, with total body clearance ranging from 125 141 mL/min. The concentration area under curve increased a dose-proportional manner. apparent elimination half-life (2 hours) did not appear be influenced by duration dosing. No accumulation observed during multiple-dose study. More than 80% administered excreted urine as unchanged cefepime, bioavailability 100%. well tolerated. Most experienced none mild pain only minimum discomfort at site injection.