The role of skull base surgery for the treatment of adenoid cystic carcinoma of the sinonasal tract.

摘要: Background Adenoid cystic carcinoma (ACC) of the sinonasal tract is an aggressive malignancy associated with a poor 5-year survival rate. The role skull base surgery for treatment patients presenting ACC and its impact upon their has not previously been evaluated. Methods A retrospective review 35 who were treated radiation therapy at University Pittsburgh Medical Center was performed to evaluate patient outcome. Results Local recurrence tumor following observed in 36% originally Center. Fourteen percent these developed regional recurrence, 21% distant metastases. We did identify any tumor-related factors that predicted outcome. Local recurrences salvage surgical excision, and, despite management, only 1 17 local considered cured (NED) 24 months (follow-up after surgery). Overall, disease-free 46.4%, median follow-up 40 months. Conclusions ACC malignancy. Skull facilitated gross total excision advanced lesions deemed inoperable past, but resulted overall improvement survival. portends very prognosis, regimens. Alternative therapies warrant further investigation. Prospective, randomized studies are necessary outcome multimodal regimens, including chemotherapeutic © 1999 John Wiley & Sons, Inc. Head Neck 21: 402–407, 1999.