Neoangiogenesis in laryngeal carcinoma: angiogenin and CD105 expression is related to carcinoma recurrence rate and disease‐free survival

摘要: Marioni G, Marino F, Blandamura S, D’Alessandro E, Giacomelli L, Guzzardo V, Lionello M, de Filippis C & Staffieri A (2010) Histopathology57, 535–543 Neoangiogenesis in laryngeal carcinoma: angiogenin and CD105 expression is related to carcinoma recurrence rate disease-free survival Aims:  Angiogenin regulates angiogenesis supporting primary metastatic tumour growth. a proliferation-associated protein expressed angiogenic endothelial cells. The aim of this study was investigate for the first time squamous cell (LSCC) evaluate relationship between expression, clinicopathological prognostic parameters. Methods results:  total 108 consecutive operable LSCCs were studied. determined immunohistochemically both cells intratumoral vessels. evaluated LSCC calculated by computer-based image analysis system. percentage fields occupied CD105-assessed microvessels determined. higher patients who experienced loco-regional disease (P = 0.032). Disease-free survival (DFS) shorter cases with showing >21.0% (P = 0.035). correlated strongly score vessels (P = 0.0000). Higher DFS high found (P = 0.0004, P = 0.0001). Conclusions:  can be considered as potentially useful detect risk might benefit from more aggressive therapy.