The clinical significance of apolipoprotein L1 in head and neck squamous cell carcinoma.
作者： Feng Zhong , Hui-Ping Lu , Gang Chen , Yi-Wu Dang , Xiao-Guohui Zhang
关键词:
摘要: Approximately 500,000 new head and neck squamous cell carcinoma (HNSCC) cases are detected every year around the world, its incidence ranks sixth among all cancer types globally. Among these cases, oral (OSCC) laryngeal (LSCC) HNSCC subtypes with high rates, especially in China. The present study examines association between apolipoprotein L1 (APOL1) mRNA protein expression clinical parameters HNSCC. two most common (oral larynx) of were selected for subgroup analyses. Immunohistochemistry (IHC) was used to detect APOL1 levels specimens. It demonstrated that 221 higher compared normal tissues. Consistent upregulation also found subgroups OSCC LSCC. Through mining ArrayExpress, Cancer Genome Atlas Gene Expression Omnibus databases, microarrays RNA sequencing data retrieved, which analyze levels. results showed both LSCC subtypes, as well HNSCC, non-cancerous epithelium. summary receiver operating characteristic analysis had potential a diagnostic biomarker Thus, may contribute tumorigenesis
spandidos.info参考文章(68)
Carsten Sticht, Kolja Freier, Karl Knöpfle, Christa Flechtenmacher, Susanne Pungs, Christof Hofele, Meinhard Hahn, Stefan Joos, Peter Lichter, Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC). Neoplasia. ,vol. 10, pp. 462- 470 ,(2008) , 10.1593/NEO.08164
Rongshou Zheng, Siwei Zhang, Wanqing Chen, Lingbin Du, Chen Zhu, Huizhang Li, Incidence and mortality of laryngeal cancer in China, 2011 Chinese Journal of Cancer Research. ,vol. 27, pp. 52- 58 ,(2018) , 10.3978/J.ISSN.1000-9604.2015.02.02
Dongmei Cheng, Allison Weckerle, Yi Yu, Lijun Ma, Xuewei Zhu, Mariana Murea, Barry I. Freedman, John S. Parks, Gregory S. Shelness, Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells Journal of Lipid Research. ,vol. 56, pp. 1583- 1593 ,(2015) , 10.1194/JLR.M059733
Antero Salminen, Kai Kaarniranta, Anu Kauppinen, Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process. Ageing Research Reviews. ,vol. 12, pp. 520- 534 ,(2013) , 10.1016/J.ARR.2012.11.004
Siqin Zhaorigetu, Guanghua Wan, Ramesh Kaini, Guanghua Wan, Zeyu Jiang, Chien-an A. Hu, ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death Autophagy. ,vol. 4, pp. 1079- 1082 ,(2008) , 10.4161/AUTO.7066
Augustine MK Choi, Stefan W Ryter, Beth Levine, None, Autophagy in human health and disease. The New England Journal of Medicine. ,vol. 368, pp. 1845- 1846 ,(2013) , 10.1056/NEJMC1303158
Meng Lian, Jugao Fang, Demin Han, Hongzhi Ma, Ling Feng, Ru Wang, Fan Yang, Microarray Gene Expression Analysis of Tumorigenesis and Regional Lymph Node Metastasis in Laryngeal Squamous Cell Carcinoma PLoS ONE. ,vol. 8, pp. e84854- ,(2013) , 10.1371/JOURNAL.PONE.0084854
Atanu K. Khatua, Amber M. Cheatham, Etty D. Kruzel, Pravin C. Singhal, Karl Skorecki, Waldemar Popik, Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1 American Journal of Physiology-cell Physiology. ,vol. 309, ,(2015) , 10.1152/AJPCELL.00384.2014
Mathias Uhlén, Linn Fagerberg, Björn M Hallström, Cecilia Lindskog, Per Oksvold, Adil Mardinoglu, Åsa Sivertsson, Caroline Kampf, Evelina Sjöstedt, Anna Asplund, IngMarie Olsson, Karolina Edlund, Emma Lundberg, Sanjay Navani, Cristina Al-Khalili Szigyarto, Jacob Odeberg, Dijana Djureinovic, Jenny Ottosson Takanen, Sophia Hober, Tove Alm, Per-Henrik Edqvist, Holger Berling, Hanna Tegel, Jan Mulder, Johan Rockberg, Peter Nilsson, Jochen M Schwenk, Marica Hamsten, Kalle Von Feilitzen, Mattias Forsberg, Lukas Persson, Fredric Johansson, Martin Zwahlen, Gunnar Von Heijne, Jens Nielsen, Fredrik Pontén, Tissue-based map of the human proteome Science. ,vol. 347, pp. 1260419- 1260419 ,(2015) , 10.1126/SCIENCE.1260419
Chien-An A. Hu, Edward I. Klopfer, Patricio E. Ray, Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease FEBS Letters. ,vol. 586, pp. 947- 955 ,(2012) , 10.1016/J.FEBSLET.2012.03.002