Editorial: Monitoring Pathophysiology in the Injured Brain.
作者： Eric Peter Thelin , Adel Helmy , David W. Nelson , Niklas Marklund
关键词:
摘要: Brain injuries can be caused by, for instance, spontaneous hemorrhages, thromboembolic incidents or traumatic events, and are considerable sources of morbidity mortality (1). commonly result in immense socioeconomic consequences due to the acute as well persisting neurological deficits (2). To date, there currently few pharmacological therapies proven clinical benefit targeting underlying pathophysiology occurring aftermath subarachnoid hemorrhage (SAH) (3), stroke (4), brain injury (TBI) (5). Although these exceedingly heterogeneous, some common pathophysiological phases may identified. At disease onset, primary ictus cause initial neuronal, glial, vascular injury, which is then followed by complex responses. The tissue exacerbated secondary insults, vulnerable during first post-injury period (6). cascades include among others neuroinflammation, energy failure, hypoxia, inadequate cerebral perfusion (7). By monitoring multiple intracerebral systemic parameters across a range modalities, time course detrimental ascertained. Importantly, knowledge acquired from investigation processes expected facilitate future development novel treatment strategies. Recently, improved intracranial was stressed one key areas research commissioned article devoted TBI Lancet Neurology editorial (8). In this Research Topic, number authors several centers excellence worldwide have shared their on injuries. These contributions provide updated other injuries, refining patient management overall goal improving outcomes detection deleterious injured brain.
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sci-hub.se 参考文章(8)
Sui-yi Xu, Su-yue Pan, The failure of animal models of neuroprotection in acute ischemic stroke to translate to clinical efficacy Medical science monitor basic research. ,vol. 19, pp. 37- 45 ,(2013) , 10.12659/MSMBR.883750
Andrew IR Maas, Nino Stocchetti, Ross Bullock, Moderate and severe traumatic brain injury in adults. Lancet Neurology. ,vol. 7, pp. 728- 741 ,(2008) , 10.1016/S1474-4422(08)70164-9
David J. Loane, Alan I. Faden, Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends in Pharmacological Sciences. ,vol. 31, pp. 596- 604 ,(2010) , 10.1016/J.TIPS.2010.09.005
B Jennett, Epidemiology of head injury. Journal of Neurology, Neurosurgery & Psychiatry. ,vol. 60, pp. 362- 369 ,(1996) , 10.1136/JNNP.60.4.362
Diego Castanares-Zapatero, Philippe Hantson, Pharmacological treatment of delayed cerebral ischemia and vasospasm in subarachnoid hemorrhage Annals of Intensive Care. ,vol. 1, pp. 12- 12 ,(2011) , 10.1186/2110-5820-1-12
Anders Gustavsson, Mikael Svensson, Frank Jacobi, Christer Allgulander, Jordi Alonso, Ettore Beghi, Richard Dodel, Mattias Ekman, Carlo Faravelli, Laura Fratiglioni, Brenda Gannon, David Hilton Jones, Poul Jennum, Albena Jordanova, Linus Jönsson, Korinna Karampampa, Martin Knapp, Gisela Kobelt, Tobias Kurth, Roselind Lieb, Mattias Linde, Christina Ljungcrantz, Andreas Maercker, Beatrice Melin, Massimo Moscarelli, Amir Musayev, Fiona Norwood, Martin Preisig, Maura Pugliatti, Juergen Rehm, Luis Salvador-Carulla, Brigitte Schlehofer, Roland Simon, Hans-Christoph Steinhausen, Lars Jacob Stovner, Jean-Michel Vallat, Peter Van den Bergh, Jim van Os, Pieter Vos, Weili Xu, Hans-Ulrich Wittchen, Bengt Jönsson, Jes Olesen, CDBE2010 Study Group, None, Cost of disorders of the brain in Europe 2010 European Neuropsychopharmacology. ,vol. 21, pp. 718- 779 ,(2011) , 10.1016/J.EURONEURO.2011.08.008
C. Werner, K. Engelhard, Pathophysiology of traumatic brain injury BJA: British Journal of Anaesthesia. ,vol. 99, pp. 4- 9 ,(2007) , 10.1093/BJA/AEM131
Andrew IR Maas, David K Menon, P David Adelson, Nada Andelic, Michael J Bell, Antonio Belli, Peter Bragge, Alexandra Brazinova, András Büki, Randall M Chesnut, Giuseppe Citerio, Mark Coburn, D Jamie Cooper, A Tamara Crowder, Endre Czeiter, Marek Czosnyka, Ramon Diaz-Arrastia, Jens P Dreier, Ann-Christine Duhaime, Ari Ercole, Thomas A Van Essen, Valery L Feigin, Guoyi Gao, Joseph Giacino, Laura E Gonzalez-Lara, Russell L Gruen, Deepak Gupta, Jed A Hartings, Sean Hill, Ji-yao Jiang, Naomi Ketharanathan, Erwin JO Kompanje, Linda Lanyon, Steven Laureys, Fiona Lecky, Harvey Levin, Hester F Lingsma, Marc Maegele, Marek Majdan, Geoffrey Manley, Jill Marsteller, Luciana Mascia, Charles McFadyen, Stefania Mondello, Virginia Newcombe, Aarno Palotie, Paul M Parizel, Wilco Peul, James Piercy, Suzanne Polinder, Louis Puybasset, Todd E Rasmussen, Rolf Rossaint, Peter Smielewski, Jeannette Söderberg, Simon J Stanworth, Murray B Stein, Nicole Von Steinbüchel, William Stewart, Ewout W Steyerberg, Nino Stocchetti, Anneliese Synnot, Braden Te Ao, Olli Tenovuo, Alice Theadom, Dick Tibboel, Walter Videtta, Kevin KW Wang, W Huw Williams, Lindsay Wilson, Kristine Yaffe, Hadie Adams, Vanni Agnoletti, Judith Allanson, Krisztina Amrein, Norberto Andaluz, Audny Anke, Anna Antoni, Arjan Bastiaan van As, Gérard Audibert, Antun Azaševac, Philippe Azouvi, Maria Luisa Azzolini, Camelia Baciu, Rafael Badenes, Karen M Barlow, Ronald Bartels, Ursula Bauerfeind, Miriam Beauchamp, Darcy Beer, Ronny Beer, Francisco Javier Belda, Bo-Michael Bellander, Rémy Bellier, Habib Benali, Thierry Benard, Valzerda Beqiri, Luigi Beretta, Francis Bernard, Guido Bertolini, Federico Bilotta, Morten Blaabjerg, Hugo den Boogert, Kathy Boutis, Pierre Bouzat, Brian Brooks, Camilla Brorsson, Monika Bullinger, Emma Burns, Emiliana Calappi, Peter Cameron, Elsa Carise, Ana M Castaño-León, Francesco Causin, Giorgio Chevallard, Arturo Chieregato, Brian Christie, Maryse Cnossen, Jonathan Coles, Johnny Collett, Francesco Della Corte, William Craig, Gabor Csato, Akos Csomos, Nicola Curry, Claire Dahyot-Fizelier, Helen Dawes, Carol DeMatteo, Bart Depreitere, Deborah Dewey, Jeroen van Dijck, Đula Đilvesi, Diederik Dippel, Kemal Dizdarevic, Emma Donoghue, Or Duek, Guy-Loup Dulière, Adelaida Dzeko, George Eapen, Carolyn A Emery, Shane English, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Junfeng Feng, Dean Fergusson, Anthony Figaji, Joanne Fleming, Kelly Foks, Gilles Francony, None, Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research Lancet Neurology. ,vol. 16, pp. 987- 1048 ,(2017) , 10.1016/S1474-4422(17)30371-X