Hypothalamic Origin of the Metabolic Syndrome X

摘要: : The conspicuous similarities between Cushing's syndrome and the Metabolic Syndrome X open up possibility that hypercortisolemia is involved also in latter. Salivary cortisol possible to measure during undisturbed conditions including perceived stressful events everyday life. Such measurements clearly show normally regulated secretion associated with excellent health anthropometric, metabolic, hemodynamic variables. Upon stress increased followed by (insulin resistance, abdominal obesity, elevated lipids, blood pressure). In a minor part of population defect, “burned-out” secretion, occurs decreased sex steroid growth hormone secretions, strong, consistent associations X. Psychosocial socioeconomic handicaps tendencies abuse depressive-anxious mood changes are consistently associated. feedback control central glucocorticoid receptors (GR) blunted, function GR abnormal. This corresponds polymorphism early gene locus, which obesity insulin resistance found 14% Swedish male population. We suggest due discretely discoverable reactions based on environmental factors expressed different impact depending genetic susceptibility.