Development Alters the Expression of Calcium Currents in Chick - limb Motoneurons
作者： David P. McCobb , Phillip M. Best , Kurt G. Beam
DOI: 10.1016/0896-6273(89)90052-4
关键词:
摘要: Calcium current types expressed in vertebrate spinal motoneurons have not been previously resolved. We resolved three chick limb identified by retrograde labeling and report that dramatic changes their expression take place during development vivo. T-, N-, L-type calcium currents were distinguished on the basis of kinetics, voltage dependence, unique pharmacological sensitivities. Developmental characterized studying isolated from embryos at stages spanning neuromuscular system development. T dominant earliest stage. Motoneurons 2 days older showed much reduced increased N L currents. suggest mature will be dominated N- may serve developmental roles.
sci-hub.se 参考文章(61)
K Gottmann, ID Dietzel, HD Lux, S Huck, H Rohrer, Development of inward currents in chick sensory and autonomic neuronal precursor cells in culture The Journal of Neuroscience. ,vol. 8, pp. 3722- 3732 ,(1988) , 10.1523/JNEUROSCI.08-10-03722.1988
Viktor Hamburger, Ronald W. Oppenheim, Naturally Occurring Neuronal Death in Vertebrates Neuroembryology. pp. 126- 142 ,(1990) , 10.1007/978-1-4899-6743-5_7
RJ O'Brien, GD Fischbach, Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro. The Journal of Neuroscience. ,vol. 6, pp. 3275- 3283 ,(1986) , 10.1523/JNEUROSCI.06-11-03275.1986
RJ O'Brien, GD Fischbach, Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures The Journal of Neuroscience. ,vol. 6, pp. 3284- 3289 ,(1986) , 10.1523/JNEUROSCI.06-11-03284.1986
MP Mattson, SB Kater, Calcium regulation of neurite elongation and growth cone motility The Journal of Neuroscience. ,vol. 7, pp. 4034- 4043 ,(1987) , 10.1523/JNEUROSCI.07-12-04034.1987
RJ O'Brien, GD Fischbach, Isolation of embryonic chick motoneurons and their survival in vitro The Journal of Neuroscience. ,vol. 6, pp. 3265- 3274 ,(1986) , 10.1523/JNEUROSCI.06-11-03265.1986
RJ O'Brien, GD Fischbach, Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists The Journal of Neuroscience. ,vol. 6, pp. 3290- 3296 ,(1986) , 10.1523/JNEUROSCI.06-11-03290.1986
CS Cohan, JA Connor, SB Kater, Electrically and chemically mediated increases in intracellular calcium in neuronal growth cones The Journal of Neuroscience. ,vol. 7, pp. 3588- 3599 ,(1987) , 10.1523/JNEUROSCI.07-11-03588.1987
D.P. McCobb, S.B. Kater, Membrane voltage and neurotransmitter regulation of neuronal growth cone motility Developmental Biology. ,vol. 130, pp. 599- 609 ,(1988) , 10.1016/0012-1606(88)90355-7
Y Yaari, B Hamon, H. Lux, Development of two types of calcium channels in cultured mammalian hippocampal neurons. Science. ,vol. 235, pp. 680- 682 ,(1987) , 10.1126/SCIENCE.2433765