Associations between orosensory perception of oleic acid, the common single nucleotide polymorphisms (rs1761667 and rs1527483) in the CD36 gene, and 6-n-propylthiouracil (PROP) tasting.
作者： Melania Melis , Giorgia Sollai , Patrizia Muroni , Roberto Crnjar , Iole Tomassini Barbarossa
DOI: 10.3390/NU7032068
关键词:
摘要: Orosensory perception of dietary fat varies in individuals, thus influencing nutritional status. Several studies associated detection and preference with CD36 or 6-n-propylthiouracil (PROP) sensitivity. Other have not confirmed the latter association. We analyzed relationship between orosensory oleic acid, two variants, PROP tasting. Thresholds acid were assessed 64 subjects using a modification three-alternative forced-choice procedure. Subjects classified for taster status genotyped TAS2R38 (SNPs: rs1761667 rs1527483). homozygous GG polymorphism showed higher sensitivity to than AA subjects. The capability detect was directly responsiveness. non-tasters had lower papilla density tasters, those genotype thresholds AA. In conclusion, results direct association tasting CD36, which play significant role non-tasters, given their low number taste papillae. Characterization individual fatty acids may important implications by explaining variations human preferences.
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