Role of E-cadherin in peritoneal dissemination of the pancreatic cancer cell line, panc-1, through regulation of cell to cell contact.
作者： Hiroaki Furuyama , Shigeki Arii , Akira Mori , Masayuki Imamura
DOI: 10.1016/S0304-3835(00)00488-2
关键词:
摘要: Abstract The present study was designed to clarify the molecules responsible for peritoneal dissemination of cancer cells. We established sublines with high (HP cells) and low (LP passing activity through membrane a transwell chamber. cell lines were from human pancreatic line, Panc-1. LP cells demonstrated an octagonal shape tight adhesion, whereas HP exhibited spindle grew less cell–cell contact in vitro. It found that degree nude mice following injection these compared subsequently investigated expression certain adhesion molecules. Consequently, we stronger E-cadherin than On other hand, there no difference CD44H β1 integrin between two sublines. Passing invasion chamber increased nearly equal levels treatment anti-human antibody. Moreover, transfection mouse cDNA into reduced both similar In conclusion, results indicated loss facilitates dissemination, playing causative role
elsevier.com
sci-hub.se 参考文章(38)
I Rodrigo, A Fabra, A Cano, M Quintanilla, A Vinyals, E Lozano, L López-Barcons, A Llorens, M Gonzalez-Garrigues, Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression Laboratory Investigation. ,vol. 78, pp. 1131- 1142 ,(1998)
Rolf J. Weinel, Kurt Neumann, Oliver Kisker, Annette Rosendahl, Expression and potential role of E-cadherin in pancreatic carcinoma. International Journal of Pancreatology. ,vol. 19, pp. 25- 30 ,(1996) , 10.1007/BF02788372
Gregory R. Mundy, Paul J. Williams, Akira Sasaki, Toshiyuki Yoneda, Toshiyuki Yoneda, Colin R. Dunstan, Gabriel Mbalaviele, E-Cadherin Expression in Human Breast Cancer Cells Suppresses the Development of Osteolytic Bone Metastases in an Experimental Metastasis Model Cancer Research. ,vol. 56, pp. 4063- 4070 ,(1996)
Hideaki Tahara, Keisuke Iihara, Masatoshi Takeichi, Takesada Mori, Hitoshi Shiozaki, Takatoshi Kadowaki, Masatoshi Inoue, Yuichiro Doki, Hiroshi Oka, Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Research. ,vol. 53, pp. 3421- 3426 ,(1993)
Setsuo Hirohashi, Masatoshi Takeichi, Yukio Shimosato, Masayuki Noguchi, Osahiko Abe, Shinji Hirano, Yutaka Shimoyama, Cadherin Cell-Adhesion Molecules in Human Epithelial Tissues and Carcinomas Cancer Research. ,vol. 49, pp. 2128- 2133 ,(1989)
J Behrens, M M Mareel, F M Van Roy, W Birchmeier, Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. Journal of Cell Biology. ,vol. 108, pp. 2435- 2447 ,(1989) , 10.1083/JCB.108.6.2435
Shigehiko Nishimura, Yong-Suk Chung, Masakazu Yashiro, Tohru Inoue, Michio Sowa, CD44H Plays an Important Role in Peritoneal Dissemination of Scirrhous Gastric Cancer Cells Japanese Journal of Cancer Research. ,vol. 87, pp. 1235- 1244 ,(1996) , 10.1111/J.1349-7006.1996.TB03138.X
Anna H. Wu, Mimi C. Yu, Thomas M. Mack, Smoking, alcohol use, dietary factors and risk of small intestinal adenocarcinoma International Journal of Cancer. ,vol. 70, pp. 512- 517 ,(1997) , 10.1002/(SICI)1097-0215(19970304)70:5<512::AID-IJC4>3.0.CO;2-0
Takahiro Yasoshima, Ryuichi Denno, Satoshi Kawaguchi, Noriyuki Sato, Yojiro Okada, Hideki Ura, Kokichi Kikuchi, Koichi Hirata, Establishment and Characterization of Human Gastric Carcinoma Lines with High Metastatic Potential in the Liver: Changes in Integrin Expression Associated with the Ability to Metastasize in the Liver of Nude Mice Japanese Journal of Cancer Research. ,vol. 87, pp. 153- 160 ,(1996) , 10.1111/J.1349-7006.1996.TB03153.X
W C Chen, B Obrink, Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells. Journal of Cell Biology. ,vol. 114, pp. 319- 327 ,(1991) , 10.1083/JCB.114.2.319