Haemorrhagic Factors from Snake Venoms II. Structures of Haemorrhagic Factors and Types and Mechanisms of Haemorrhage

作者: Hiroshi Mashiko , Hidenobu Takahashi

DOI: 10.3109/15569549809040406

关键词:

摘要: AbstractIt was revealed that almost all snake venom haemorrhagic factors (HFs) are metalloproteinases. Analysis of primary structures HFs they share multi-domain structures. And divided into four major classes. These damaged the micro blood vessel walls and cause local haemorrhage. Some systemic, organ specific species This review describes autoproteolysis HFs. Types mechanisms haemorrhage caused by also described.

参考文章(80)
Jón B. Bjarnason, Jay W. Fox, [21] Snake venom metalloendopeptidases: Reprolysins Proteolytic Enzymes: Aspartic and Metallo Peptidases. ,vol. 248, pp. 345- 368 ,(1995) , 10.1016/0076-6879(95)48023-4
Bjarnason Jb, Fox Jw, Hamilton D, Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom. Biological chemistry Hoppe-Seyler. pp. 121- ,(1988)
A. T. Tu, C. L. Ownby, J. Bjarnason, Hemorrhagic toxins from rattlesnake (Crotalus atrox) venom. Pathogenesis of hemorrhage induced by three purified toxins. American Journal of Pathology. ,vol. 93, pp. 201- 218 ,(1978)
Niewiarowski S, Kloczewiak M, Stewart Gj, McLane Ma, Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors Seminars in Hematology. ,vol. 31, pp. 289- 300 ,(1994)
Jay W. Fox, Jón B. Bjarnason, [22] Atrolysins: Metalloproteinases from Crotalus atrox venom Proteolytic Enzymes: Aspartic and Metallo Peptidases. ,vol. 248, pp. 368- 387 ,(1995) , 10.1016/0076-6879(95)48024-2
Hiroyuki Takeya, Shinji Nishida, Norikazu Nishino, Yuichi Makinose, Tamotsu Omori-Satoh, Toshiaki Nikai, Hisayoshi Sugihara, Sadaaki Iwanaga, Primary structures of platelet aggregation inhibitors (disintegrins) autoproteolytically released from snake venom hemorrhagic metalloproteinases and new fluorogenic peptide substrates for these enzymes. Journal of Biochemistry. ,vol. 113, pp. 473- 483 ,(1993) , 10.1093/OXFORDJOURNALS.JBCHEM.A124069
Toshiyuki Miyata, Hiroyuki Takeya, Yasushi Ozeki, Mitsue Arakawa, Fuminori Tokunaga, Sadaaki Iwanaga, Tamotsu Omori-Satoh, Primary Structure of Hemorrhagic Protein, HR2a, Isolated from the Venom of Trimeresurus flavoviridis1 The Journal of Biochemistry. ,vol. 105, pp. 847- 853 ,(1989) , 10.1093/OXFORDJOURNALS.JBCHEM.A122756
H Takeya, K Oda, T Miyata, T Omori-Satoh, S Iwanaga, The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis. Journal of Biological Chemistry. ,vol. 265, pp. 16068- 16073 ,(1990) , 10.1016/S0021-9258(17)46189-8
J D Shannon, E N Baramova, J B Bjarnason, J W Fox, Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin. Journal of Biological Chemistry. ,vol. 264, pp. 11575- 11583 ,(1989) , 10.1016/S0021-9258(18)80102-8