Study of activation of murine T cells with bacterial superantigens. In vitro induction of enhanced responses in CD4+ T cells and of anergy in CD8+ T cells.

摘要: Primary and secondary responses of murine CD4+ T cells CD8+ upon stimulation with staphylococcal enterotoxin E (SEE) bearing superantigenic properties were examined. Both isolated C57BL/6 splenic proliferated produced IL-2 IFN-gamma SEE in substantial levels. The amounts greater those somewhat cells. SEE-induced lymphoblasts, larger parts which bore the V beta 11 element their TCR, proliferated, IFN-gamma, showed toxin-dependent cytotoxicity levels restimulation SEE. By contrast, part element, did not show first two three at all SEE, whereas these cytotoxicity. lymphoblasts suppress reactivity lymphoblasts. comparable rIL-2 or mAb to CD3 11.