Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol.

摘要: Introduction The emergence and rapid spread of COVID-19 have caused widespread catastrophic public health economic impact, requiring governments to restrict societal activity reduce the disease. role household transmission in population SARS-CoV-2, host immunity limiting transmission, is poorly understood. This paper describes a protocol for prospective observational study cohort households Liverpool City Region, UK, which addresses SARS-CoV-2 between members how immunological response infection changes over time. Methods analysis Households not previously tested positive with nucleic acid amplification test, are followed up an initial period 12 weeks. Participants asked provide weekly self-throat nasal swabs record their presence symptoms. Incidence secondary attack rates measured. Transmission will be investigated against range demographic behavioural variables. Blood faecal samples collected at several time points evaluate immune responses prevalence risk factors shedding respectively. Ethics dissemination has received approval from National Health Service Research Committee; REC Reference: 20/HRA/2297, IRAS Number: 283 464. Results disseminated through scientific conferences peer-reviewed open access publications. A report findings also shared participants. quantify scale determinants SARS-CoV-2. Additionally, before during different stages analysed, adding understanding by severity.