Dendritic cells and immune-based therapies.

摘要: The dendritic cell (DC) lineage of white blood cells specializes in capturing antigens and stimulating T-dependent immunity. Because their efficacy inducing T responses vivo without other adjuvants, DCs can be considered "nature's adjuvant." are the least abundant leukocytes, but methods for generating large numbers being developed. Ex vivo, develop from CD34+ progenitors cultured presence a combination granulocyte-macrophage colony-stimulating factor (GM-CSF) tumor necrosis factor-alpha (TNF-alpha). This kind work is interest charging with clinically relevant active immunity patients. Targeting to may become feasible also because identification distinct antigen receptors such as DEC-205, DECalectin 10 contiguous, C-type lectin domains. DEC-205 mediate adsorptive uptake presentation via DCs. AIDS another disease which should designing new therapies, since play major role promoting HIV-1 replication. Many isolates induce syncytia between CD4+ memory cells. These turn site productive infection HIV-1, possibly requisite transcription factors like NF-kappaB Sp1 separately provided by cells, respectively. Further attention DC provide avenues manipulating immune system several clinical contexts.