Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi.

摘要: Although the majority of patients with acute Lyme disease can be cured standard 2-4 week antibiotic treatment, about 10-20% continue suffering from chronic symptoms described as post-treatment syndrome (PTLDS). While cause for this is debated, one possibility that persister bacteria are not killed by current antibiotics and remain active in system. It has been reported essential oils have antimicrobial activities some used persisting symptoms. However, activity against causative agent Borrelia burgdorferi (B. burgdorferi) well studied. Here, we evaluated 34 B. stationary phase culture a model bacteria. We found all had culture, top 5 (oregano, cinnamon bark, clove bud, citronella, wintergreen) at low concentration 0.25% showing high anti-persister more than known drug daptomycin. Interestingly, highly were to excellent anti-biofilm ability shown their dissolve aggregated biofilm-like structures. The 3 hits, oregano, bark bud completely eradicated viable cells without any regrowth subculture fresh medium, whereas but citronella wintergreen did effect. Carvacrol was most ingredient oregano oil cells, while other ingredients p-cymene α-terpinene no apparent activity. Future studies needed characterize optimize combination vitro vivo address safety pharmacokinetic properties before they considered novel treatment persistent disease.