摘要: The trisomy 18 and 13 syndromes represent important common conditions of human aneusomy. Together, their combined prevalence in live-born infants approaches 1 4000 births. These are unique among chromosome disorders as well the other described this text since about 90% children with trisomies die before first birthday. Because high infant mortality rate, sometimes labeled simplistically “lethal.” However, 10% do indeed survive. Regardless figures for survival, parents child practitioners caring family seek an approach to management health supervision any serious medical disorder. Ongoing support care by professionals crucial a whose has uncertain prognosis. This chapter will provide concise review literature plan primary 13. Keywords: trisomy 19; trisomy 13; Edwards syndrome; Patau syndrome; poor survival; multiple congenital anomalies