Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.

作者: Hirotaka Shibuya , Chinami Kitamura , Shoji Maehara , Marie Nagahata , Hendig Winarno

DOI: 10.1248/CPB.51.71

关键词:

摘要: The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from pubescens was investigated. filamentous fungus Xylaria sp. found to transform the into their 1-N-oxide derivatives.

参考文章(7)
Guy Dodin, Christine Cordier, Laurence Menager, Aicha Bourzegue, Jean-Claude Blais, A novel route to new carbonyl derivatives of cinchonine and cinchonidine Journal of The Chemical Society-perkin Transactions 1. pp. 3619- 3622 ,(1998) , 10.1039/A803854F
Theodor W. Guentert, John J. Daly, Sidney Riegelman, Isolation, characterisation and synthesis of a new quinidine metabolite European Journal of Drug Metabolism and Pharmacokinetics. ,vol. 7, pp. 31- 38 ,(1982) , 10.1007/BF03189540
Ernest Wenkert, Jasjit S Bindra, Ching-Jer Chang, David W Cochran, Fred M Schell, None, Carbon-13 nuclear magnetic resonance spectroscopy of naturally occurring substances. Alkaloids Accounts of Chemical Research. ,vol. 7, pp. 46- 51 ,(1974) , 10.1021/AR50074A003
T Tsuboi, DC Kaslow, M.M.G. Gozar, M Tachibana, Y-M Cao, M Toni, Antigenic polymorphism of novel ookinete surface proteins, PVS25 and PVS28 from Plasmodium vivax that are candidates of transmission-blocking vaccine Parasitology International. ,vol. 47, pp. 59- ,(1998) , 10.1016/S1383-5769(98)80108-6
Jin Sung Lee, Kwan Soo Ko, Hack Sung Jung, Phylogenetic analysis of Xylaria based on nuclear ribosomal ITS1-5. 8S-ITS2 sequences. Fems Microbiology Letters. ,vol. 187, pp. 89- 93 ,(2000) , 10.1111/J.1574-6968.2000.TB09142.X
S. Siebers-Wolff, H.-A. Arfmann, W.-R. Abraham, K. Kieslich, Microbiological Hydroxylation and N-Oxidation of Cinchona Alkaloids Biocatalysis. ,vol. 8, pp. 47- 58 ,(1993) , 10.3109/10242429309030955