The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases.
作者： Spyros I. Siakavellas , Petros P. Sfikakis , Giorgos Bamias
DOI: 10.1016/J.SEMARTHRIT.2015.02.007
关键词:
摘要: Abstract Importance TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) decoy (DcR3) are members of the TNF superfamilies proteins, respectively. They constitute a system that actively interferes with regulation immune responses may participate in pathogenesis autoimmune diseases. Objectives This review aims to present current knowledge on role TL1A/DR3/DcR3 pathophysiology rheumatic diseases, focus rheumatoid arthritis (RA). Methods An extensive literature search was performed PubMed database using following keywords: TL1A, 3, DR3, DcR3, TNFSF15, TNFRSF25, TNFSF6B. Studies were assessed selected view their relevance Conclusion The axis is novel pathway participates variety These molecules be promising therapeutic targets for inflammatory arthritis.
elsevier.com
sci-hub.se 参考文章(80)
Chun Hsiung Chen, Wei Sheng Chen, Chung Tei Chou, Hsien Tzung Liao, Ming Han Chen, Chang Youh Tsai, Overexpression of decoy receptor 3 in synovial tissues of inflammatory arthritis. Clinical and Experimental Rheumatology. ,vol. 30, pp. 171- 177 ,(2012)
C.-S. Lee, C.-Y. Hu, H.-F. Tsai, C.-S. Wu, S.-L. Hsieh, L.-C. Liu, P.-N. Hsu, Elevated serum decoy receptor 3 with enhanced T cell activation in systemic lupus erythematosus Clinical and Experimental Immunology. ,vol. 151, pp. 383- 390 ,(2008) , 10.1111/J.1365-2249.2007.03579.X
Eddie C. Y. Wang, Zarabeth Newton, Olivia A. Hayward, Stephen R. Clark, Fraser Collins, William V. Perks, Ravinder K. Singh, Jason P. Twohig, Anwen S. Williams, Regulation of early cartilage destruction in inflammatory arthritis by death receptor 3. Arthritis & Rheumatism. ,vol. 66, pp. 2762- 2772 ,(2014) , 10.1002/ART.38770
John L. Prehn, Lisa S. Thomas, Carol J. Landers, Qi T. Yu, Kathrin S. Michelsen, Stephan R. Targan, The T Cell Costimulator TL1A Is Induced by FcγR Signaling in Human Monocytes and Dendritic Cells Journal of Immunology. ,vol. 178, pp. 4033- 4038 ,(2007) , 10.4049/JIMMUNOL.178.7.4033
Giorgos Bamias, Kostas Evangelou, Theognosia Vergou, Katerina Tsimaratou, Garyfallia Kaltsa, Christina Antoniou, Athanasios Kotsinas, Sungee Kim, Vassilis Gorgoulis, Alexander J. Stratigos, Petros P. Sfikakis, Upregulation and nuclear localization of TNF-like cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions. Experimental Dermatology. ,vol. 20, pp. 725- 731 ,(2011) , 10.1111/J.1600-0625.2011.01304.X
G. S. Firestein, Every Joint Has a Silver Lining Science. ,vol. 315, pp. 952- 953 ,(2007) , 10.1126/SCIENCE.1139574
Robert M. Pitti, Scot A. Marsters, David A. Lawrence, Margaret Roy, Frank C. Kischkel, Patrick Dowd, Arthur Huang, Christopher J. Donahue, Steven W. Sherwood, Daryl T. Baldwin, Paul J. Godowski, William I. Wood, Austin L. Gurney, Kenneth J. Hillan, Robert L. Cohen, Audrey D. Goddard, David Botstein, Avi Ashkenazi, Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer Nature. ,vol. 396, pp. 699- 703 ,(1998) , 10.1038/25387
Konstantinos A. Papadakis, Daocheng Zhu, John L. Prehn, Carol Landers, Armine Avanesyan, Gina Lafkas, Stephan R. Targan, Dominant Role for TL1A/DR3 Pathway in IL-12 plus IL-18-Induced IFN-γ Production by Peripheral Blood and Mucosal CCR9+ T Lymphocytes The Journal of Immunology. ,vol. 174, pp. 4985- 4990 ,(2005) , 10.4049/JIMMUNOL.174.8.4985
David Q. Shih, Kathrin S. Michelsen, Robert J. Barrett, Eva Biener-Ramanujan, Rivkah Gonsky, Xiaolan Zhang, Stephan R. Targan, Insights into TL1A and IBD Pathogenesis Advances in Experimental Medicine and Biology. ,vol. 691, pp. 279- 288 ,(2011) , 10.1007/978-1-4419-6612-4_29
Tingyu Qin, Upregulation of DR3 expression in CD4⁺ T cells promotes secretion of IL-17 in experimental autoimmune uveitis. Molecular Vision. ,vol. 17, pp. 3486- 3493 ,(2011)