Small Animal Imaging in Development of New Generation Diagnostic and Therapeutic Agents
作者： Tuulia Huhtala , Ale Nrvne
DOI: 10.5772/34263
关键词:
摘要: Imaging technologies form an inseparable part of molecular medicine and is a major research focus globally. potential therapeutic or diagnostic agents in animal models the early stage important step towards pre-clinical clinical trials humans. The resent achievements biology, virology nanotechnology provide totally new approaches to deliver patient starting from conventional small molecules virus based gene therapy. This creates need for better tools pharmaceutical research. Small imaging provides excellent method development generation agents.
intechopen.com
sci-hub.st 参考文章(120)
Thrall Jh, Technetium-99m labeled agents for skeletal imaging. CRC critical reviews in clinical radiology and nuclear medicine. ,vol. 8, pp. 1- 31 ,(1976)
A. E. Bolton, W. M. Hunter, The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay Biochemical Journal. ,vol. 133, pp. 529- 538 ,(1973) , 10.1042/BJ1330529
J. J. Marchalonis, An enzymic method for the trace iodination of immunoglobulins and other proteins. Biochemical Journal. ,vol. 113, pp. 299- 305 ,(1969) , 10.1042/BJ1130299
Christoph Bremer, Vasilis Ntziachristos, Ralph Weissleder, Optical-based molecular imaging: contrast agents and potential medical applications. European Radiology. ,vol. 13, pp. 231- 243 ,(2003) , 10.1007/S00330-002-1610-0
Erkki Koivunen, Wadih Arap, Heli Valtanen, Aija Rainisalo, Oula Penate Medina, Pia Heikkilä, Carmela Kantor, Carl G. Gahmberg, Tuula Salo, Yrjö T. Konttinen, Timo Sorsa, Erkki Ruoslahti, Renata Pasqualini, Tumor targeting with a selective gelatinase inhibitor Nature Biotechnology. ,vol. 17, pp. 768- 774 ,(1999) , 10.1038/11703
W. M. S. Russell, R. L. Burch, The principles of humane experimental technique ,(1992)
Jan Bornschein, Ignat Drozdov, Peter Malfertheiner, Octreotide LAR: safety and tolerability issues Expert Opinion on Drug Safety. ,vol. 8, pp. 755- 768 ,(2009) , 10.1517/14740330903379525
FC GREENWOOD, WM HUNTER, JS GLOVER, THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY Biochemical Journal. ,vol. 89, pp. 114- 123 ,(1963) , 10.1042/BJ0890114
F. Wiekhorst, C. Seliger, R. Jurgons, U. Steinhoff, D. Eberbeck, L. Trahms, C. Alexiou, Quantification of magnetic nanoparticles by magnetorelaxometry and comparison to histology after magnetic drug targeting. Journal of Nanoscience and Nanotechnology. ,vol. 6, pp. 3222- 3225 ,(2006) , 10.1166/JNN.2006.477
Fernando Rivera, Maria Eugenia Vega-Villegas, Marta Francisca López-Brea, Cetuximab, its clinical use and future perspectives Anti-Cancer Drugs. ,vol. 19, pp. 99- 113 ,(2008) , 10.1097/CAD.0B013E3282F23287