The Selectins and their Ligands: Adhesion Molecules of the Vasculature

摘要: Publisher Summary Leukocyte rolling and adhesion to endothelium are dynamic processes that involve multiple receptors the active participation of cells involved. Current data obtained from in vitro vivo assays, gene-targeted mice, antibody-blocking studies demonstrate leukocyte is likely result cumulative additive interactions with several molecules contributing both specialized redundant ways. Selectin expression critical for capturing leukocytes streaming blood, while synergistic action selectins some integrins contribute selectin-mediated rolling. Regulatory mechanisms control these events include rapid mobilization presynthesized P-selectin cell surface, increased rates selectin protein synthesis, induced transcription E-selectin gene, changes cycling E- surface intracellular compartments, shedding L-selectin activation-induced avidity ligands, alterations cytoskeletal associations. The ligand function through induction their differential glycosylation, release also important regulatory events. by various subclasses diverse beds vascular allows considerable specificity migration into tissues at sites inflammation, wound healing, immune responses.