Chapter 14 Sinistrality and Psychopathology

摘要: Publisher Summary The patterns of cerebral organization that determine sinistrality, although partially understood in certain instances, remain obscure and enigmatic others. A variety psychopathological disorders are associated with an excess lefthanders the afflicted individuals: autism, forms schizophrenia, bipolar (but not unipolar) affective illnesses, susceptibility to dysphoric mood states, types criminal psychopathy (particularly if recidivistic), epilepsy psychosis. Intellectual retardation is also increased sinistrality. evidence reviewed chapter shows incidence psychiatric sinistral populations. origins consequences sinistrality schizophrenia different monozygotic twins, dizygotic singletons. multiple as determinants Both fundamentally related a functional alteration dominant hemispheric systems. pattern brain may be result genetic influences, compensatory left hemisphere damage, especially sustained before age five years. brain-damage model fits general population schizophrenics severe manifestation illness: early onset males, absence family history for psychosis structural pathology specifically involving hemisphere. Modern suggests hemisphere, through contralateral inhibitory regulation, modulates emotional aggression-related neural subsystems right