Dysregulation of GAS5 and OIP5-AS1 lncRNAs in periodontitis

作者: Arezou Sayad , Soudeh Ghafouri-Fard , Saba Sadeghpour , Sara Mirzajani , Mohammad Taheri

DOI: 10.1016/J.GENREP.2020.100712

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摘要: Abstract Periodontitis as a multifactorial disorder has been associated with dysregulation of several genes which contribute in regulation immune responses. Recently, number studies have addressed the role long non-coding RNAs (lncRNAs) pathogenesis this disorder. In current study, we evaluated expression two lncRNAs, namely GAS5 and OIP5-AS1 peripheral blood tissues samples patients periodontitis healthy subjects using quantitative real time PCR. Expression was significantly lower obtained from compared normal controls (Posterior beta RE = −2.677, P value

参考文章(21)
Gay Carter, Branko Miladinovic, Achintya A. Patel, Lauren Deland, Stephen Mastorides, Niketa A. Patel, Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus. BBA clinical. ,vol. 4, pp. 102- 107 ,(2015) , 10.1016/J.BBACLI.2015.09.001
Andreas Petri, Karen Dybkær, Martin Bøgsted, Charlotte Albæk Thrue, Peter H. Hagedorn, Alexander Schmitz, Julie Støve Bødker, Hans Erik Johnsen, Sakari Kauppinen, Long Noncoding RNA Expression during Human B-Cell Development PLOS ONE. ,vol. 10, pp. e0138236- ,(2015) , 10.1371/JOURNAL.PONE.0138236
E M Coccia, C Cicala, A Charlesworth, C Ciccarelli, G B Rossi, L Philipson, V Sorrentino, Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development. Molecular and Cellular Biology. ,vol. 12, pp. 3514- 3521 ,(1992) , 10.1128/MCB.12.8.3514
M E K Haywood, S J Rose, S Horswell, M J Lees, G Fu, M J Walport, B J Morley, Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes. Genes and Immunity. ,vol. 7, pp. 250- 263 ,(2006) , 10.1038/SJ.GENE.6364294
Yu Nagahama, Takashi Obama, Michihiko Usui, Yukari Kanazawa, Sanju Iwamoto, Kazushige Suzuki, Akira Miyazaki, Tomohiro Yamaguchi, Matsuo Yamamoto, Hiroyuki Itabe, Oxidized low-density lipoprotein-induced periodontal inflammation is associated with the up-regulation of cyclooxygenase-2 and microsomal prostaglandin synthase 1 in human gingival epithelial cells. Biochemical and Biophysical Research Communications. ,vol. 413, pp. 566- 571 ,(2011) , 10.1016/J.BBRC.2011.09.002
P. M. Preshaw, A. L. Alba, D. Herrera, S. Jepsen, A. Konstantinidis, K. Makrilakis, R. Taylor, Periodontitis and diabetes: a two-way relationship Diabetologia. ,vol. 55, pp. 21- 31 ,(2012) , 10.1007/S00125-011-2342-Y
Bo Johanneson, Guadalupe Lima, Jenny von Salomé, Donato Alarcón-Segovia, Marta E. Alarcón-Riquelme, A Major Susceptibility Locus for Systemic Lupus Erythemathosus Maps to Chromosome 1q31 American Journal of Human Genetics. ,vol. 71, pp. 1060- 1071 ,(2002) , 10.1086/344289
M. Mourtada-Maarabouni, V. L. Hedge, L. Kirkham, F. Farzaneh, G. T. Williams, Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5). Journal of Cell Science. ,vol. 121, pp. 939- 946 ,(2008) , 10.1242/JCS.024646
T. Kino, D. E. Hurt, T. Ichijo, N. Nader, G. P. Chrousos, Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid Receptor Science Signaling. ,vol. 3, ,(2010) , 10.1126/SCISIGNAL.2000568
NJ Kassebaum, Eduardo Bernabé, M Dahiya, B Bhandari, CJL Murray, W Marcenes, None, Global Burden of Severe Periodontitis in 1990-2010 A Systematic Review and Meta-regression Journal of Dental Research. ,vol. 93, pp. 1045- 1053 ,(2014) , 10.1177/0022034514552491