Tumor Antigens and Immune Regulation in Cancer Immunotherapy
作者： Rong-Fu Wang , Helen Y. Wang
DOI: 10.1007/978-1-4419-9914-6_21
关键词:
摘要: The importance of T-cell-mediated antitumor immunity has been demonstrated in both animal models and human cancer immunotherapy. identification tumor antigens from various types generated a resurgence interest immunotherapy for provides the stage to develop therapeutic vaccines. However, recent clinical studies indicate that by peptide or DC/peptide vaccines is not sufficient eradicate cancer. One major factors weak transient immune response presence suppression microenvironment. Regulatory T cells myeloid-derived suppressor are cell responsible suppression. Novel strategies have developed enhancing T-cell responses against overcoming Combination antigen-specific stimulate effector with anti-immune opportunities developing effective
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sci-hub.st 参考文章(179)
Philip D. Greenberg, Adoptive T cell therapy of tumors: mechanisms operative in the recognition and elimination of tumor cells. Advances in Immunology. ,vol. 49, pp. 281- 355 ,(1991) , 10.1016/S0065-2776(08)60778-6
E. Appella, J. R. Yannelli, M. El-Gamil, Y. Kawakami, S. A. Rosenberg, P. F. Robbins, K. Sakaguchi, Rongfu Wang, Xiaoqiang Kang, Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes. Journal of Immunology. ,vol. 155, pp. 1343- 1348 ,(1995)
Steven A. Rosenberg, Panida Tong-On, Yong Li, John P. Riley, Mona El-Gamil, Maria R. Parkhurst, Paul F. Robbins, Identification of BING-4 Cancer Antigen Translated From an Alternative Open Reading Frame of a Gene in the Extended MHC Class II Region Using Lymphocytes From a Patient With a Durable Complete Regression Following Immunotherapy The Journal of Immunology. ,vol. 168, pp. 2402- 2407 ,(2002) , 10.4049/JIMMUNOL.168.5.2402
Jun Lu, Esteban Celis, Hiroya Kobayashi, Identification of helper T-cell epitopes that encompass or lie proximal to cytotoxic T-cell epitopes in the gp100 melanoma tumor antigen. Cancer Research. ,vol. 61, pp. 7577- 7584 ,(2001)
Maria R. Parkhurst, Yutaka Kawakami, Scott Southwood, Steven A. Rosenberg, Ellen B. Fitzgerald, Alessandro Sette, Identification of a Shared HLA-A*0201-restricted T-Cell Epitope from the Melanoma Antigen Tyrosinase-related Protein 2 (TRP2) Cancer Research. ,vol. 58, pp. 4895- 4901 ,(1998)
Edith M. Janssen, Edward E. Lemmens, Tom Wolfe, Urs Christen, Matthias G. von Herrath, Stephen P. Schoenberger, CD4 + T cells are required for secondary expansion and memory in CD8 + T lymphocytes Nature. ,vol. 421, pp. 852- 856 ,(2003) , 10.1038/NATURE01441
Mark J. Smyth, Gavin P. Dunn, Robert D. Schreiber, Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity Advances in Immunology. ,vol. 90, pp. 1- 50 ,(2006) , 10.1016/S0065-2776(06)90001-7
Helen Y. Wang, Guangyong Peng, Zhong Guo, Ethan M. Shevach, Rong-Fu Wang, Recognition of a New ARTC1 Peptide Ligand Uniquely Expressed in Tumor Cells by Antigen-Specific CD4+ Regulatory T Cells Journal of Immunology. ,vol. 174, pp. 2661- 2670 ,(2005) , 10.4049/JIMMUNOL.174.5.2661
Paolo Tarsini, Giorgio Parmiani, Licia Rivoltini, Francesco Gallino, Francesca Rini, Arabella Mazzocchi, Fernando Ravagnani, Filiberto Belli, Chiara Castelli, Novel HLA-Cw8-Restricted T Cell Epitopes Derived from Tyrosinase-Related Protein-2 and gp100 Melanoma Antigens Journal of Immunology. ,vol. 162, pp. 1739- 1748 ,(1999)
Naoyuki Miyokawa, Hajime Iizuka, Makoto Katagiri, Keisuke Sato, Kazuhiro Asano, Hidetoshi Takahashi, Taku Kokubo, Hiroya Kobayashi, Shoji Kimura, CD4+ T cells from peripheral blood of a melanoma patient recognize peptides derived from nonmutated tyrosinase. Cancer Research. ,vol. 58, pp. 296- 301 ,(1998)