Developmental changes in 7-ethoxyresorufin-O-deethylase (EROD) and δ-aminolevulinic acid dehydratase (ALA-D) activities in three passerines

作者: Susanna Tanhuanpää , Tapio Eeva , Esa Lehikoinen , Mikko Nikinmaa

DOI: 10.1016/S0742-8413(99)00066-3

关键词:

摘要: Abstract In this study, we report changes in 7-ethoxyresorufin-O-deethylase (EROD) and δ-aminolevulinic acid dehydratase (ALA-D) enzyme activities during development of three wild passerine bird species: pied flycather (Ficedula hypoleuca), great tit (Parus major) blue (P. caeruleus). Activities were determined from late embryos, newly hatched, 1-week-old 15-day-old nestlings adult birds. EROD activity hepatic microsomes ALA-D liver tissue erythrocytes measured. all species investigated increased the first posthatching week decreased thereafter. Also, differences between late-term adults seen. Based on these results, suggest that developmental status an animal must always be taken into account when evaluating results obtained biomarker studies.

参考文章(27)
T. K. Basu, J. W. T. Dickerson, D. V. W. Parke, Effect of development on the activity of microsomal drug-metabolizing enzymes in rat liver. Biochemical Journal. ,vol. 124, pp. 19- 24 ,(1971) , 10.1042/BJ1240019
T.D. Porter, M.J. Coon, Cytochrome P-450 : multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms Journal of Biological Chemistry. ,vol. 266, pp. 13469- 13472 ,(1991) , 10.1016/S0021-9258(18)92717-1
Richard T. Mayer, M. Danny Burke, ETHOXYRESORUFIN: DIRECT FLUORIMETRIC ASSAY OF A MICROSOMAL O-DEALKYLATION WHICH IS PREFERENTIALLY INDUCIBLE BY 3-METHYLCHOLANTHRENE Drug Metabolism and Disposition. ,vol. 2, pp. 583- 588 ,(1974)
D. Mauzerall, S. Granick, THE OCCURRENCE AND DETERMINATION OF δ-AMINOLEVULINIC ACID AND PORPHOBILINOGEN IN URINE Journal of Biological Chemistry. ,vol. 219, pp. 435- 446 ,(1956) , 10.1016/S0021-9258(18)65809-0
S J Yaffe, B R Sonawane, R G Thurman, L A Reinke, Postnatal development of mixed-function oxidation and conjugation in hemoglobin-free perfused rat liver. Journal of Pharmacology and Experimental Therapeutics. ,vol. 216, pp. 473- 478 ,(1981)
Moreno Paolini, Laura Pozzetti, Andrea Sapone, Gian Luigi Biagi, Giorgio Cantelli-Forti, Development of basal and induced testosterone hydroxylase activity in the chicken embryo in ovo. British Journal of Pharmacology. ,vol. 122, pp. 344- 350 ,(1997) , 10.1038/SJ.BJP.0701352
David J. Hoffman, J. Christian Franson, Oliver H. Pattee, Christine M. Bunck, Helen C. Murray, Biochemical and hematological effects of lead ingestion in nestling American kestrels (Falco sparverius). Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. ,vol. 80, pp. 431- 439 ,(1985) , 10.1016/0742-8413(85)90080-5
Jerry F. Payne, Linda L. Fancey, Anver D. Rahimtula, Edward L. Porter, Review and perspective on the use of mixed-function oxygenase enzymes in biological monitoring. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. ,vol. 86, pp. 233- 245 ,(1987) , 10.1016/0742-8413(87)90074-0