[131I]MIBG and topotecan: a rationale for combination therapy for neuroblastoma.

摘要: Abstract MIBG is selectively concentrated in neuroblastoma cells, and radioiodinated has been used with some success for targeted radiotherapy. However, long-term cure remains elusive, the topoisomerase I inhibitor topotecan may improve upon existing [ 131 I]MIBG therapy. While synergistic killing by combinations of ionising radiation inhibitors reported, there no consensus on optimal scheduling. Furthermore, attempt to demonstrate radiopotentiation We are investigating various scheduled preliminary data suggests that induces increased accumulation vitro.