Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex

摘要: Previous studies have reported inconsistent effects of dietary restriction (DR) on cortical inhibition. To clarify this issue, we examined the response properties neurons in primary visual cortex (V1) DR and control groups cats using vivo extracellular single-unit recording techniques, assessed synthesis inhibitory neurotransmitter GABA V1 from both immunohistochemical Western blot techniques. Our results showed that to stimuli was significantly modified by DR, as indicated an enhanced selectivity for stimulus orientations motion directions, decreased visually-evoked response, lowered spontaneous activity increased signal-to-noise ratio relative cats. Further, it shown that, accompanied with these changes neuronal responsiveness, immunoreactivity expression a key GABA-synthesizing enzyme GAD67 were DR. These demonstrate may retard brain aging increasing intracortical inhibition effect improve function information processing. This DR-induced elevation favor modulating energy expenditure based food availability.