Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.

摘要: We have examined the influence of V1/V2 region human immunodeficiency virus type 1 (HIV-1) gp120 on certain biologic properties virus. observed that genomic background T-cell-line-tropic strain, HIV-1SF2mc, both V1 and V2 domains macrophage-tropic HIV-1SF162mc, in addition to required V3 domain, are necessary attain full macrophage tropism. Furthermore, domain modulates sensitivity HIV-1 soluble CD4 neutralization. Structural studies recombinant mutant envelope glycoproteins suggest function is interact with confer HIV-1SF2mc a conformation more similar strain HIV-1SF162mc. The appears be specific plays an important role determining tissue tropism Images