Paroxysmal pulmonary edema consequent to stimulation of cardiovascular receptors

摘要: Abstract The part played by mechanical and neurogenic factors in pulmonary edema experimentally produced dogs the use of a standard technique has been investigated. basis this is rapid, interrupted infusion saline solution into carotid arteries toward brain. 1. quantity injected fluid may be considered as submaximal, sense that, while favors development distending vessels, amount administered insufficient itself to produce edema. 2. importance specific receptors cardiovascular apparatus demonstrated. Their stimulation causes reflex leading increased permeability capillaries, if these vessels are already distended. problem whether first dilatation or its effect result direct increase needs further study. most important among reflexes carotido-pulmonary whose afferent pathway central nervous system through glossopharyngeal nerve, efferent lungs fibers which anatomically sympathetic system. Another that elicited distention heart chambers. A third reflex, cannot yet measured, artery-pulmonary reflex. All able cause when submaximal fluid, edema, circulation. 3. Deeper understanding mechanism can obtained only using drugs either enhance inhibit studying means biologic assay properties both blood fluid. 4. Electrical cardiac end cut vagi intact nerves causing extreme bradycardia. This factor, however, does not play any role experiments with technique.