HISTOCOMPATIBILITY DETERMINANTS IN MULTIPLE SCLEROSIS, WITH SPECIAL REFERENCE TO CLINICAL COURSE
作者： Casper Jersild , GreteS Hansen , Arne Svejgaard , Torben Fog , Mogens Thomsen
DOI: 10.1016/S0140-6736(73)90970-7
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摘要: Abstract Twenty-eight randomly selected patients with multiple sclerosis (M.S.) were typed in the mixed-lymphocyte culture test for a specific lymphocyte determinant LD-7a by means of homozygous stimulator cells. Nineteen (70%) positive, frequency much higher than 16% observed healthy individuals. Thirteen carried HL-A7, and all these which is significantly different (p=0·004) from about 56% this twenty-five normal HL-A7 positive Of remaining fifteen patients, six LD-7a, also (p=0·009) that negatives (three forty individuals). Family studies showed character inherited not acquired. The progression disease was (P
sci-hub.se 参考文章(12)
S. NAITO, N. NAMEROW, M. R. MICKEY, P. I. TERASAKI, Multiple Sclerosis: Association with HL—A3 Tissue Antigens. ,vol. 2, pp. 1- 4 ,(2008) , 10.1111/J.1399-0039.1972.TB00111.X
F. H. Bach, M. B. Widmer, M. Segall, M. L. Bach, J. Klein, Genetic and immunological complexity of major histocompatibility regions. Science. ,vol. 176, pp. 1024- 1027 ,(1972) , 10.1126/SCIENCE.176.4038.1024
E. J. Yunis, D. B. Amos, Three Closely Linked Genetic Systems Relevant to Transplantation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 68, pp. 3031- 3035 ,(1971) , 10.1073/PNAS.68.12.3031
Fritz H. Bach, Michael B. Widmer, Marilyn L. Bach, Jan Klein, SEROLOGICALLY DEFINED AND LYMPHOCYTE-DEFINED COMPONENTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE MOUSE Journal of Experimental Medicine. ,vol. 136, pp. 1430- 1445 ,(1972) , 10.1084/JEM.136.6.1430
L. Ellman, I. Green, W. J. Martin, B. Benacerraf, Linkage between the Poly-L-Lysine Gene and the Locus Controlling the Major Histocompatibility Antigens in Strain 2 Guinea Pigs Proceedings of the National Academy of Sciences of the United States of America. ,vol. 66, pp. 322- 328 ,(1970) , 10.1073/PNAS.66.2.322
C. Jersild, A. Svejgaard, T. Fog, T. Ammitzbøll, HL-A Antigens and Diseases. I. Multiple Sclerosis Tissue Antigens. ,vol. 3, pp. 243- 250 ,(2008) , 10.1111/J.1399-0039.1973.TB01002.X
Bo Dupont, Vagn Andersen, Grete S??nderstrup Hansen, Arne Svejgaard, Abnormal mixed lymphocyte reactions in the family of a patient with severe combined immunodeficiency. Transplantation. ,vol. 14, pp. 557- 563 ,(1972) , 10.1097/00007890-197211000-00005
H. O. McDevitt, A. Chinitz, Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type Science. ,vol. 163, pp. 1207- 1208 ,(1969) , 10.1126/SCIENCE.163.3872.1207
A. SVEJGAARD, M. HAUGE, F. KISSMEYER-NIELSEN, E. THORSBY, HL-A haplotype frequencies in Denmark and Norway. Tissue Antigens. ,vol. 1, pp. 184- 195 ,(2008) , 10.1111/J.1399-0039.1971.TB00096.X
J. BERTRAMS, E. KUWERT, U. LIEDTKE, HL-A antigens and multiple sclerosis. Tissue Antigens. ,vol. 2, pp. 405- 408 ,(2008) , 10.1111/J.1399-0039.1972.TB00060.X