Prevalence of phototherapy induced hypocalcemia in term neonate.

摘要: Hyperbilirubinemia is a common and in most cases benign clinical condition neonates. Phototherapy used for management of neonatal hyperbilirubinemia[1]. may lead to complications including skin rash, diarrhea, hyperthermia, chills, dehydration, DNA damage lymphocytes, retinal degeneration, bronze baby syndrome especially cholestatic jaundice PDA opening LBWs Hypocalcemia[2]. A cross sectional study was performed on 147 icteric neonates managed with phototherapy Bahrami Hospital Tehran from 2008 2009. provided four blue light fluorescent lamps (Phillips) placed at 20 cm distance newborns. Neonates any underlying disease or risk factors hypocalcemia were excluded. Serum calcium bilirubins measured arrival 48 hours after phototherapy. We considered as total serum <8 mg/dl. Demographic data, bilirubin levels recorded analyzed by ANOVA, Banferroni Chi-square tests. P value <0.05 significant. The approved Ethics Committee University Medical Sciences. A written informed consent taken one the parents prior enrollment explaining study. The done term infants (73 females, 74 males). mean±SD chronological age time appearance 6±3 days 3±2days respectively. weight 3182±430 gram level 20.1±3.3 mg/dl admission. The admission 9.8±0.8 9.5±0.9 respectively (Table 1). Eighty-three (56%) babies had decrease level. Only ten (7%) newborns (4.2% 10.4% males) developed There significant difference between before (P=0.03). Table 1 Serum phototherapy Romagnoli[3] first suggest association hypocalcaemia preterms. Hakinson[4] Hunter[5] hypothesized that inhibits pineal secretion melatonin which blocks effect cortisol bone calcium. So increases uptake induces hypocalcaemia. Kim[6] suggested decreased parathormone cause hypocalcemia. In Hooman's urinary excretion significantly higher group[7]. Yadav[8] observed 66% 80% preterms prevalence Jain's study[9] 30% full Ehsanipoor's 15%[10]. our 83 decline level, only 7% like Karamifar's (8.7%)[11]. frequency patients high bilirubin. In Eghbalian's study, hypocalcemic apnea[12]. Yadav's became symptomatic, sign jitteriness[8]. none symptoms similar findings[11]. In conclusion it be assessed treated hrs more accordingly. It seems associated not so we recommend further larger studies estimation this rate.