Changes in Endogenous Dopamine Induced by Methylphenidate Predict Functional Connectivity in Nonhuman Primates.

摘要: Dopamine (DA) levels in the striatum are increased by many therapeutic drugs, such as methylphenidate (MPH), which also alters behavioral and cognitive functions thought to be controlled prefrontal cortex (PFC) dose-dependently. We linked DA changes functional connectivity (FC) using simultaneous [ 18 F]fallypride PET resting state magnetic resonance imaging (fMRI) awake male rhesus monkeys after oral administration of various doses MPH. found a negative correlation between nondisplaceable binding potential (BP ND ) MPH dose head caudate (hCd), demonstrating extracellular resulting from administration. This decrease BP was negatively correlated with FC hCd PFC. Subsequent voxel-wise analyses revealed correlations dorsolateral PFC, hippocampus, precuneus. These results, showing that MPH-induced predict FC, shed light on mechanism striatal could influence function SIGNIFICANCE STATEMENT transmission is play an essential role shaping large scale-neural networks underlie functions. It target drugs (Ritalin), blocks dopamine transporter, thereby increasing levels. Methylphenidate used extensively treat ADHD, even though its effects their underlying neural mechanisms not well understood. To date, little known about link brain organization. Using PET/MR we show methylphenidate-induced endogenous this structure cortex, precuneus, hippocampus.