Hypoxia-Induced Oxidative Stress in Ischemic Retinopathy
作者： Suk-Yee Li , Zhong Jie Fu , Amy C. Y. Lo
DOI: 10.1155/2012/426769
关键词:
摘要: Oxidative stress plays a crucial role in the pathogenesis of retinal ischemia/hypoxia, complication ocular diseases such as diabetic retinopathy (DR) and prematurity (ROP). refers to imbalance between production reactive oxygen species (ROS) ability scavenge these ROS by endogenous antioxidative systems. Free radicals are implicated irreversible damage cell membrane, DNA, other cellular structures oxidizing lipids, proteins, nucleic acids. Anti-oxidants that can inhibit oxidative processes protect cells from ischemic/hypoxic insults. In particular, treatment using anti-oxidants vitamin E lutein, inhibition nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) or related signaling pathways, administration catalase superoxide dismutase (SOD) possible therapeutic regimens for DR, ROP, ischemic diseases. The DR ROP well underlying mechanisms involved hypoxia/ischemia-induced is discussed. information provided will be beneficial understanding developing effective interventions treat stress-induced damages.
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