DIFFERENT EFFECTS OF RESVERATROL ON HUMAN THP-1 MONOCYTES AND THP-1 DIFFERENTIATED MACROPHAGES
作者： Li Feng
DOI:
关键词:
摘要: Resveratrol (Res), a natural polyphenol compound found in grapes and red wine has been shown to exhibit anti-tumor, anti-oxidant anti-inflammation effects. However, the molecular targets as well mechanisms of action contributing health promoting effects Res are largely unknown. In our study, through dietary or pharmaceutical consumption levels, we investigated on inflammation-driven immune responses human THP-1 monocytes Phorbol 12-myristate 13-acetate (PMA) differentiated THP-1-derived (P-THP-1) macrophages. Our results showed that induced anti-proliferation with S phase arrest at concentrations, and, however, cell apoptosis caused G0/G1 concentrations. addition, different pro-inflammatory cytokines lines. Furthermore, similar analysis pterostilbene genistein revealed possible effect was attributed specific stilbene structure. conclusion, resveratrol appeared play roles inflammatory response P-THP-1 cells.
参考文章(93)
Igor Akushevich, Julia Kravchenko, Kenneth G. Manton, Herbert Kim Lyerly, Cancer mortality and morbidity patterns in the U.S. population : an interdisciplinary approach Springer. ,(2009)
Cristina Rius, May Abu-Taha, Carlos Hermenegildo, Laura Piqueras, Jose-Miguel Cerda-Nicolas, Andrew C. Issekutz, Luís Estañ, Julio Cortijo, Esteban J. Morcillo, Francisco Orallo, Maria-Jesus Sanz, Trans- but Not Cis-Resveratrol Impairs Angiotensin-II–Mediated Vascular Inflammation through Inhibition of NF-κB Activation and Peroxisome Proliferator-Activated Receptor-γ Upregulation Journal of Immunology. ,vol. 185, pp. 3718- 3727 ,(2010) , 10.4049/JIMMUNOL.1001043
Claude Libert, Manuela Cappelletti, Giuseppe Lattanzio, Valeria Poli, Gennaro Ciliberto, Piero Musiani, Massimo Aquilina, Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice American Journal of Pathology. ,vol. 151, pp. 689- 696 ,(1997)
Min-fu Tsan, Julie E. White, Jewraj G. Maheshwari, G. Chikkappa, Anti-leukemia effect of resveratrol Leukemia & Lymphoma. ,vol. 43, pp. 983- 987 ,(2002) , 10.1080/10428190290021669
Henry P. Ciolino, Grace Chao Yeh, Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Molecular Pharmacology. ,vol. 56, pp. 760- 767 ,(1999)
Masayuki Shiseki, S Perwez Hussain, Peijun He, Curtis C Harris, Makoto Nagashima, Koh Miura, Shu Okamura, Yuzuru Araki, Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. Cancer Research. ,vol. 63, pp. 728- 734 ,(2003)
Joseph Katz, Heft Marc, Stephen Porter, Jim Ruskin, Inflammation, periodontitis, and coronary heart disease. The Lancet. ,vol. 358, pp. 1998- ,(2001) , 10.1016/S0140-6736(01)06989-6
Sharmila Shankar, Gyanendra Singh, Rakesh K Srivastava, Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential Frontiers in Bioscience. ,vol. 12, pp. 4839- 4854 ,(2007) , 10.2741/2432
Ana I. Romero-Pérez, Maite Ibern-Gómez, Rosa M. Lamuela-Raventós, M. Carmen de la Torre-Boronat, Piceid, the Major Resveratrol Derivative in Grape Juices Journal of Agricultural and Food Chemistry. ,vol. 47, pp. 1533- 1536 ,(1999) , 10.1021/JF981024G
Yong-Hong Feng, Yi-Na Zhu, Jin Liu, Yong-Xing Ren, Jian-Yi Xu, Yi-Fu Yang, Xiao-Yu Li, Jian-Ping Zou, Differential regulation of resveratrol on lipopolysacchride-stimulated human macrophages with or without IFN-γ pre-priming International Immunopharmacology. ,vol. 4, pp. 713- 720 ,(2004) , 10.1016/J.INTIMP.2004.02.006