Pregnane X Receptor in Drug Development

作者: Su Sien , Yue-Ming Wang , Sergio C. , Taosheng Che

DOI: 10.5772/27753

关键词:

摘要:

参考文章(160)
Xiaochao Ma, Yatrik Shah, Connie Cheung, Grace L. Guo, Lionel Feigenbaum, Kristopher W. Krausz, Jeffrey R. Idle, Frank J. Gonzalez, The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metabolism and Disposition. ,vol. 35, pp. 194- 200 ,(2007) , 10.1124/DMD.106.012831
Grace L Guo, Jeff S Moffit, Christopher J Nicol, Jerrold M Ward, Lauren A Aleksunes, Angela L Slitt, Steven A Kliewer, Jose E Manautou, Frank J Gonzalez, Enhanced acetaminophen toxicity by activation of the pregnane X receptor Toxicological Sciences. ,vol. 82, pp. 374- 380 ,(2004) , 10.1093/TOXSCI/KFH286
Linda C. Quattrochi, A. Scott Mills, Joyce L. Barwick, Charles B. Yockey, Philip S. Guzelian, A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids. Journal of Biological Chemistry. ,vol. 270, pp. 28917- 28923 ,(1995) , 10.1074/JBC.270.48.28917
Andrew Carr, Katherine Samaras, Donald J Chisholm, David A Cooper, Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance. The Lancet. ,vol. 351, pp. 1881- 1883 ,(1998) , 10.1016/S0140-6736(98)03391-1
Tomoe Ichikawa, Kuniko Horie-Inoue, Kazuhiro Ikeda, Bruce Blumberg, Satoshi Inoue, Steroid and Xenobiotic Receptor SXR Mediates Vitamin K2-activated Transcription of Extracellular Matrix-related Genes and Collagen Accumulation in Osteoblastic Cells Journal of Biological Chemistry. ,vol. 281, pp. 16927- 16934 ,(2006) , 10.1074/JBC.M600896200
Russell Ross, Atherosclerosis — An Inflammatory Disease The New England Journal of Medicine. ,vol. 340, pp. 115- 126 ,(1999) , 10.1056/NEJM199901143400207
Sean Ekins, Leonid Mirny, Erin G. Schuetz, A Ligand-Based Approach to Understanding Selectivity of Nuclear Hormone Receptors PXR, CAR, FXR, LXRα, and LXRβ Pharmaceutical Research. ,vol. 19, pp. 1788- 1800 ,(2002) , 10.1023/A:1021429105173
Katryn Allen, Hartmut Jaeschke, Bryan L. Copple, Bile Acids Induce Inflammatory Genes in Hepatocytes: A Novel Mechanism of Inflammation during Obstructive Cholestasis American Journal of Pathology. ,vol. 178, pp. 175- 186 ,(2011) , 10.1016/J.AJPATH.2010.11.026
Timothy W. Synold, Isabelle Dussault, Barry Marc Forman, The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nature Medicine. ,vol. 7, pp. 584- 590 ,(2001) , 10.1038/87912