Control of Self‐Renewal and Differentiation of Hematopoietic Stem Cells: HOXB4 on the Threshold
作者： HANNES KLUMP , BERNHARD SCHIEDLMEIER , CHRISTOPHER BAUM
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摘要: The homeodomain transcription factor HOXB4 is one of the most attractive tools to expand hematopoietic stem cells in vitro and vivo promote formation from differentiated embryonic cells. However, expression levels compatible with favorable effect enhanced self-renewal without perturbing differentiation, vivo, remain be determined. In this paper, we discuss necessity define "therapeutic width" expression, based on observations our lab others that demonstrate ectopic leads a concentration-dependent perturbation lineage differentiation mouse human summary, combined results argue favor existence certain threshold for activity control behavior progenitor Indeed, existing evidence suggests dosage effects ectopically expressed factors may more rule than an exception.
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