New azaspiracids in Amphidomataceae (Dinophyceae)

摘要: Abstract Azaspiracids (AZAs) are a group of lipophilic polyether toxins implicated in incidents shellfish poisoning humans, particularly northern Europe, which produced by the small marine dinoflagellate Azadinium spinosum . Other related species/strains Amphidomataceae have not been proven to date contain any known azaspiracids. Closer analyses these triple quadrupole mass spectrometry precursor and product ion mode now revealed four new compounds with high similarity azaspiracids, all them characteristic m / z 348 fragment but absence 362 fragment. These were detected three species/strains, i.e. North Sea isolates poporum (molecular mass: 845.5 Da), Korean isolate has designated as A. cf. 857.5 Da) Amphidoma languida isolated from Bantry Bay, Ireland masses: 815.5 829.5 Da). Cell quotas roughly 2–20 fg per cell same range found for AZA-1/-2 Structures proposed interpretation fragmentation patterns resolution measurements using Fourier transform cyclotron resonance-mass (FTICR-MS).