NLRP1 and NTN1, Deregulated Blood Differentially Methylated Regions in Mild Cognitive Impairment Patients.

摘要: Epigenetic dysregulation has been known to be involved in neurodegenerative diseases, including amnestic mild cognitive impairment (MCI). The aim of this study was investigate the genome-wide DNA methylation analysis, order identify epigenetic blood from patients with MCI. Here, we investigated whether MCI and such an aberration could detected circulation. Genome-wide bisulfite sequencing targeted 84 million bases covering 3.7 CpG sites comparatively analyzed control groups. And correlation between transcriptomic changes sought. Significant differentially methylated regions (DMRs) distinguishing groups were identified functionally annotated. Most DMRs specific enriched – 2 kb + 2 kb island start located within or near gene promoters. Representative hypo- hypermethylated confirmed correlated mRNA expression comparative delta Ct method. aberrations involving metal ion homeostasis, axon growth, inflammasome, others may less-invasive, easily measurable biomarker candidates for