Role of Nutraceuticals on Nrf2 and Its Implication in Cancer Prevention
作者： Constance Lay-Lay Saw , Ah-Ng Tony Kong
DOI: 10.1007/978-94-007-2630-7_4
关键词:
摘要: “Nutraceuticals” have recently become a hot topic for the commercial world and biomedical community. It is postulated that nutraceuticals are relatively non-toxic food supplements with many health benefits including prevention of cancer. Many antioxidants by nature; isothiocyanates polyphenols been extensively researched in laboratories ours. This chapter will cover from mechanistic perspectives, how they would interact Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which master regulator antioxidant response to counteract oxidative stress. Nrf2 deficient (knockout; KO) mice lack some nutraceutical cancer chemopreventive agents suggesting important role prevention. also shown protective function against inflammation, pathological process implicated diseases carcinogenesis. Scientific evidence on anti-oxidative stress coupled anti-inflammatory be discussed this chapter.
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