Blood glucose clearance after feeding and exercise in polysaccharide storage myopathy

摘要: Polysaccharide storage myopathy (PSSM) in Quarter Horses (QH) and QH crosses is a glycogen disorder which blood glucose clearance insulin sensitivity, following an i.v. or oral challenge, are enhanced. Exercise known also to enhance uptake into skeletal muscle many animal species. Therefore, the purpose of this study was compare effect exercise on PSSM control horses when carbohydrate meal (8 Mcal sweet feed) fed either 12 h fasting alone (NEX protocol) standard protocol (EX protocol). In NEX protocol, fasted then were 8 megacalories (Mcal) feed (2.3 kg). EX 2 after test (SET). Blood analysed for < 480 min feeding. Muscle biopsies taken before protocol. With mean all concentrations significantly lower fed-PSSM than controls (P 0.013). The caused less pronounced percentage change concentration from baseline feeding compared (mean peak 26.5% vs. 70.2%, respectively) 0.0003). horses, resulted percent (44.7 67.5%, = 0.021). magnitude difference with that seen PSSM-EX 44.7% controls, 0.006). No significant differences insulin:glucose ratios found between EX. ratio increased NEX. conclusion, normal results enhanced without altering ratios. At rest, have however, increases This may explain beneficial daily preventing rhabdomyolysis PSSM.