Methylenetetrahydrofolate reductase (MTHFR) 677C>T gene polymorphism as a possible factor for reducing clinical severity of psoriasis.

摘要: Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in homocysteine/methionine metabolism. It catalysis the formation of 5-methyltetrahydrofolate (5-methyl-THF), which methyl donor for synthesis methionine from homocysteine (Hcy). Decreases folate consumption due to MTHFR polymorphism may affect production rate keratinocytes had faster reproduction rates with continuous DNA turnover and this clinical picture psoriasis. This study aimed investigate correlation C677T polymorphisms gene severity psoriasis evaluate status plasma Hcy, vitamin B12 levels patient chronic plaque The included 60 patients were genotyped using PCR (Qiagen). Psoriasis Area Severity Index (PASI) score below 7 was defined as mild, between 12 moderate, above severe disease. There significant difference disease classification (p 12) observed 38.46% wild type (CC), but only 12.50% homozygote (TT) 7.69% heterozygote (CT) patients. Significant differences Hcy noted TT CT genotypes respectively (p=0.025 p=0.040). Plasma not correlated PASI score. Our data indicate possible