The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys
作者： Christopher A. Podlesnik , Mei-Chuan Ko , Gail Winger , Jürgen Wichmann , Eric P. Prinssen
DOI: 10.1007/S00213-010-2012-7
关键词:
摘要: Rationale The synthetic nonpeptide NOP (nociceptin/orphanin FQ peptide) receptor agonist Ro 64-6198 produces antinociception in rhesus monkeys. In rodents, it has much more variable effects on pain responses, but response rate-increasing punished operant behavior and decreases drug reward.
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