Insights into regeneration tool box: An animal model approach

摘要: For ages, regeneration has intrigued countless biologists, clinicians, and biomedical engineers. In recent years, significant progress made in identification characterization of a tool kit helped the scientific community to understand mechanism(s) involved across animal kingdom. These mechanistic insights revealed that evolutionarily conserved pathways like Wnt, Notch, Hedgehog, BMP, JAK/STAT are regeneration. Furthermore, advancement high throughput screening approaches transcriptomic analysis followed by proteomic validations have discovered many novel genes, specific enhancers highly regenerative species Hydra, Planaria, Newts, Zebrafish. Since genetic machinery is kingdom, it possible engineer these genes with limited properties Drosophila, mammals. models versatile genetically tractable, cross-species comparative studies can generate for animals long gestation periods e.g. Newts. addition, will allow extrapolation capabilities from low potential, future, studies, along tissue engineering applications, strong implications field medicine stem cell biology.