Renal Acid–Base Regulation Via Ammonia Transport in Mammals

作者: I. David Weiner

DOI: 10.1007/978-1-60327-229-2_13

关键词:

摘要: Maintenance of acid–base homeostasis is fundamental to all mammals. This maintained through two mechanisms, respiratory control CO2 excretion and renal net acid excretion. Renal comprises titratable excretion, ammonia bicarbonate Quantitatively, the most significant component under physiologic pathophysiologic circumstances. includes dual components an intrarenal ammoniagenesis, followed by segment transporter-specific transport both molecular forms ammonia, NH4 + NH3.Coordinated NH3 results in exquisitely regulated thereby maintenance system at pH homeostasis.

参考文章(119)
M A Knepper, NH4+ transport in the kidney. Kidney International. ,vol. 33, ,(1991)
A. Sahai, R. L. Tannen, Biochemical pathways and modulators of renal ammoniagenesis. Mineral and Electrolyte Metabolism. ,vol. 16, pp. 249- 258 ,(1990)
Dieter Häussinger, Wouter H. Lames, Antoon F.M. Moorman, Hepatocyte heterogeneity in the metabolism of amino acids and ammonia. Enzyme. ,vol. 46, pp. 72- 93 ,(1992) , 10.1159/000468779
Uwe Ludewig, Electroneutral ammonium transport by basolateral rhesus B glycoprotein The Journal of Physiology. ,vol. 559, pp. 751- 759 ,(2004) , 10.1113/JPHYSIOL.2004.067728
Anne-Marie Marini, Giorgio Matassi, Virginie Raynal, Bruno André, Jean-Pierre Cartron, Baya Chérif-Zahar, The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Nature Genetics. ,vol. 26, pp. 341- 344 ,(2000) , 10.1038/81656
P. M. Ambuhl, M. Amemiya, M. Danczkay, M. Lotscher, B. Kaissling, O. W. Moe, P. A. Preisig, R. J. Alpern, Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney American Journal of Physiology-renal Physiology. ,vol. 271, ,(1996) , 10.1152/AJPRENAL.1996.271.4.F917
H Amlal, M Bichara, M Paillard, NH4+ transport pathways in cells of medullary thick ascending limb of rat kidney. NH4+ conductance and K+/NH4+(H+) antiport. Journal of Biological Chemistry. ,vol. 269, pp. 21962- 21971 ,(1994) , 10.1016/S0021-9258(17)31742-8
Mark Haas, Bliss Forbush III, The Na-K-Cl Cotransporters Journal of Bioenergetics and Biomembranes. ,vol. 30, pp. 161- 172 ,(1998) , 10.1023/A:1020521308985
Zhi Liu, Cheng-Han Huang, The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping. Biochemical Genetics. ,vol. 37, pp. 119- 138 ,(1999) , 10.1023/A:1018726303397
M A Knepper, S M Ginns, C A Ecelbarger, R A Coleman, X He, J B Wade, J Terris, Immunolocalization of the secretory isoform of Na-K-Cl cotransporter in rat renal intercalated cells. Journal of The American Society of Nephrology. ,vol. 7, pp. 2533- 2542 ,(1996) , 10.1681/ASN.V7122533