Preventive effect of dapsone on renal scarring following mannose-sensitive piliated bacterial infection.

摘要: Renal scarring has been thought to occur in the later stages of chronic pyelonephritis. We previously reported that mannose-sensitive (MS) piliated bacteria promoted renal scarring, which was prevented by antioxidants. The preventive effect diaphenylsulfone (dapsone), a scavenging activity on active oxygen species, examined. Female Sprague-Dawley rats were inoculated with clinical isolates Serratia marcescens had both MS and mannose-resistant pili or recombinant strains their surface; they then administered 20 mg/kg dapsone not. Dapsone significantly suppressed following infection kidney. bacterial counts kidneys not different dapsone-treated nontreated rats. conclude is effective preventing it suggested use this drug may prevent scar formation