Systematic Review and Meta-Analysis of Interventions to Improve Access and Coverage of Adolescent Immunizations.

摘要: Vaccination strategies are among the most successful and cost-effective public health for preventing disease death. Until recently, of existing immunization programs targeted infants children younger than 5 years which have successfully resulted in reducing global infant child mortality. Adolescent has been relatively neglected, leaving a quarter world's population underimmunized hence vulnerable to number preventable diseases. In recent years, large launched increase uptake different vaccines adolescents; however, recommended vaccination coverage adolescent overall remains very low, especially low- middle-income countries. received significantly more attention since advent human papillomavirus (HPV) vaccine 2006. However, only half girls United States single dose HPV while merely 43% 33% two three doses, respectively. We systematically reviewed literature published up December 2014 included 23 studies on effectiveness interventions improve adolescents. Moderate-quality evidence suggested an by 78% (relative risk: 1.78; 95% confidence interval: 1.41–2.23). Review findings suggest that including implementing requirement school, sending reminders, national permissive recommendation potential uptake. Strategies significant decrease prevalence 44% genital warts 33%; quality was low. Analysis from with or low–quality varicella deaths, measles incidence, rubella susceptibility, incidence pertussis impact nonsignificant mumps their respective vaccines. Further rigorous is needed evaluate the effectiveness adolescents