作者: Rosario Cuomo , Gerardus Koek , Daniel Sifrim , Jozef Janssens , Jan Tack
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摘要: Some methodological in vitro observations concerning bile reflux monitoring (Bilitec) suggested that Bilitec is underestimating an acid environment. Moreover, other studies showed the area above cutoff level of bilirubin absorbance would provide adequate quantitative marker for duodenal contents. Our aim was to study whether correction intraesophageal acidity and during affects results correlation with pH measurement esophageal lesions. In 84 patients (46 men; mean age 46 +/- 2.7 years) evaluated suspected gastroesophageal disease, we performed ambulatory 24-hr after upper gastrointestinal endoscopy. We obtained total area, percent time, by computer software. The factor based on literature data acidified (0.06 < 3.6; 0.21 2.6). Endoscopy revealed esophagitis grade 1-2 (E1-2) 3-4 (E3-4) 23 16 patients, respectively. A progressive increase mixed (acid + bile) occurred increasing severity endoscopic lesions (E3-4 vs no esophagitis, P 0.05). pathologic result present same 35 before between time not improved (r = 0.386 r 0.391; 0.14 (abs x min) 7.8 2.2 without 11.7 4.4 17.0 4.2 E1-2 E3-4 groups, respectively regarding 0.427, 0.01) or below 4 0.280, 0.05) considering level. Correction has only a minor effect monitoring. Taking into account surface rather than does improve