Olfactory bulbectomy in methamphetamine-treated rat mothers induces impairment in somatic and functional development of their offspring.

摘要: Olfactory bulbectomy in rodents is considered a putative model of depression. Depression often associated with drug addiction. Our previous studies demonstrated that methamphetamine (MA) administration to rat mothers affects both, and their pups. The aim the present study was examine effect bulbectomy, as depression, MA on behavior postnatal development Adult female Wistar rats were randomly divided into two groups: bulbectomized (OBX) sham-operated (SH). A period 20 days allowed for depressive-like phenotype. Animals tested motor activity test 2 % sucrose preference anhedonia hyperactive locomotor response novel environment, respectively. After then females impregnated. Pregnant exposed daily subcutaneous (s.c.) injection (5 mg/kg) or saline (SA) during entire gestation period. Postnatally, maternal pup examined. challenge dose (1 mg/kg, s.c.) further examined adult male offspring. results showed no differences matter only OBX slept more than all SH controls. Pups from born lower birthweight gained less weight pups Both, administration, delayed eyes opening. As functional pups, procedure impaired performance Bar-holding test, but group. OBX/SA group worst relative other groups. In addition, dropped boluses suggesting they stressed. offspring, increased immobility SA/SA Prenatal exposure locomotion, while decreasing immobility. adulthood distance traveled, rearing, average maximal velocity, grooming. conclusion, our suggest phenotype induces impairment somatic